SARS-CoV-2 targets MAVS for immune evasion
نویسندگان
چکیده
A new study shows that the SARS-CoV-2 nucleocapsid protein represses antiviral type I interferon response through direct interaction with signalling adaptor MAVS. Targeting this process might be a useful therapeutic strategy to boost immunity against COVID-19.
منابع مشابه
SARS-COV-2 Virus; Immune Responses and The Immunopathogenesis
Abstract Background and Objectives Clinical features of SARS-COV-2 virus include fever, headache, cough, sore throat, and shortness of breath, and in severe forms it leads to disseminated intravascular coagulation, septic shock, and ultimately death. Excessive secretion of proinflammatory cytokines such as TNF-α, IL-6, and IL-1 leads to cytokine storms in this disease. The emergence of new va...
متن کاملSerology Testing for SARS-CoV-2: Benefits and Challenges
As COVID-19 was declared as a pandemic by the World Health Organization (WHO) in March 2020, it is an emerging need to discuss different aspects of this pandemic. In any pandemic, valid and rapid laboratory diagnostic tests are critically important for early diagnosis, which will increase the rate of successful treatment and more importantly prevent the spread of the disease.
متن کاملSARS-CoV-2 infection: its psychiatric manifestations
Background: The clinical presentation of SARS-CoV-2 infection was initially dominated by respiratory symptoms. However the clinical spectrum is wide and neuropsychiatric syndromes are also a source of medical concern. Our aims are to present an atypical clinical presentation of SARS-CoV-2 infection characterized by auditory hallucinations and unusual behavior and to emphasize the diversity of ...
متن کاملمروری به بررسی ایمونولوژیکی SARS-Cov-2
زمینه و هدف بیماری کووید-19 یک بیماری عفونی به‌شدت مسری می‌باشد که توسط یک کروناویروس جدید ایجاد می‌شود که می‌تواند از انسان به انسان از طریق تماس نزدیک منتقل شود. هدف از مطالعه حاضر بررسی اطلاعات جدید در زمینه ایمونولوژی کووید-19 می‌باشد. مواد و روش‌ها در مطالعه مروری حاضر، از موتورهای جستجوی Google و Google Scholar و مقالات نمایه شده در پایگاه‌های علمی معتبر بین‌المللی از جمله Pub Med، MedLi...
متن کاملImmunological and Clinical Aspects of Immune Responses to SARS-CoV-2
The Coronavirus Disease 2019 (COVID-19) caused by a coronavirus named SARS-CoV-2 from the family Coronaviridae, was first reported in December 2019 in China. The disease have mild or severe symptoms such as fever, chills, cough, shortness of breath, body aches, and gastrointestinal symptoms, followed by severe inflammation, cytokine storm, acute respiratory distress syndrome, and dysfunction of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2021
ISSN: ['1476-4679', '1465-7392']
DOI: https://doi.org/10.1038/s41556-021-00712-y